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This is because of the hormonal fluctuations that may occur due to the use of testosterone supplements. Hence, men with existing gynecomastia should avoid hormonal therapy. Allergic Reaction to Hormone Treatment People who have earlier developed an allergic reaction to hormone replacement therapy, should refrain from taking testosterone injections. Pregnancy Though testosterone therapy may be recommended for menopausal women, it must not be taken by women who can get pregnant. It may cause birth defects, and cause a female fetus to develop male characteristics. Those who have been diagnosed with diabetes, high cholesterol levels, blood clotting problems, liver problems, congestive heart failure, or a high red blood cell count should also avoid testosterone replacement therapy. In case of men who suffer from hypogonadism, a condition wherein the testes don't produce sufficient amounts of testosterone, doctors suggest the administration of 50 to 400 mg of testosterone every two to four weeks. Unlike gels and creams, testosterone injections are much cheaper. While injections are administered less frequently (once in two or three weeks), gels need to be applied more often. Injections are safer than gels, as any form of topical formulation can cause serious complications in children who come in direct or indirect contact with it.

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